|
KMID : 0644120080210040036
|
|
Journal of Oriental Gynecology
2008 Volume.21 No. 4 p.36 ~ p.48
|
|
|
Anti-inflammatory Effect of Fructus Chaenomelis(FC)
|
|
Lee Su-Jeong
Kim Song-Baek
Choe Chang-Min
Lee Key-Sang
Cho Han-Baek
|
|
|
Abstract
|
|
|
Purpose: The purpose of this study is to investigate anti-inflammatory effect and immune responses of aqueous extract from Fructus Chaenomelis (FC).
Methods: We studied anti-inflammatory effect by means of examining the production of NO(nitric oxide) and expressions of pro-inflammatory cytokine (TNF-(tumor necrosis factor-alpha), IL(Interleukin)-6, IL-12) in the LPS-induced peritoneal macrophages of mice. Also, The western blot analysis has been done to look into the mechanism of anti-inflammatory effect.
Results: 1. The FC extract did not have any cytotoxicity in the peritoneal macrophages. 2. The FC extract inhibits the productions of NO, IL-6. IL-12 in the LPS-stimulated peritoneal macrophages of mice, but not of TNF-α. 3. The FC extract inhibits the activation of NF-κB (nuclear factor-kappa B) by keeping IκB-α (inhibitory kappa B-alpha) from degradating, but not of MAPKs(mitogen-activated protein kinases) such as ERK(extracelluar signa 1-regulated kinase), JNK(c-Jun N-terminal kinase), p38.
Conclusion: These results show that FC extract inhibits the production of pro-inflammatory cytokines such as IL-6. IL-12. NO by inhibiting NF-κB activation in the peritoneal macrophages of mice. In conclusion, this experiment suggests that FC extract may be effective for the treatment of acute and chronic inflammation including genitourinary infection.
|
|
|
KEYWORD
|
|
|
Fructus Chaenomelis(FC), NO, cytokine, MAPK, NF-κB, inflammation
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
|
|